Reference of 324-03-8, These common heterocyclic compound, 324-03-8, name is 6-Fluoroindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
compound 119 6-fluoroindoline-2,3-dione (15.05 g, 91.1mmol), urea (5.47g, 91.1mmol), p-TSA (7.85 g, 45.57 mmol) and methyl acetoacetate (10.6 g, 91.1 mmol) in acetonitrile (500 mL) was refluxed overweekend. The reaction mixture was allowed to cool to room temperature. The precipitate was filtered off. The precipitate was taken up in CH2CI2 (1L) and saturated NaHC03 solution (500mL). The mixture was stirred vigorously during 15 minutes. The precipitate was filtered off and dried in vacuo, resulting in compound 119 as a beige powder (9.25 g). Method A; Rt: 0.61 m/z : 323.1 (M+NH4)+ Exact mass: 305.1; 1H NMR (400 MHz, DMSO-dg) delta ppm 2.24 (s, 3 H), 3.32 (s, 3 H), 6.57 (dd, J=9.4, 2.3 Hz, 1 H), 6.63 – 6.75 (m, 1 H), 7.13 (dd, J=8.0, 5.6 Hz, 1 H), 7.81 (s, 1 H), 8.31 – 11.56 (m, 2 H).
Statistics shows that 6-Fluoroindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 324-03-8.
Reference:
Patent; JANSSEN R&D IRELAND; VANDYCK, Koen; HACHE, Geerwin Yvonne Paul; ROMBOUTS, Geert; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard; WO2013/102655; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem