Synthetic Route of 169037-23-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A solution of Ca(OH)2 (38.5 g, 519 mmol) and 5-(trifluoromethoxy)isatin (40 g, 173 mmol) in water (150 ml) was heated at 80C for 1 h. The heating bath was removed followed by slow addition of chloroacetone (34.5 ml, 433 mmol). The reaction was then heated at 80C for another 5 h then cooled to RT and quenched with IN aq. HCl until pH=2. The solid was filtered over fritted disk, washed with water and dried overnight at 50C under high vacuum to afford the product intermediate (47.0 g, 95% yield) as a slightly yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Trifluoromethoxy)indoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MERCK CANADA INC.; BARA, Thomas; BHAT, Sathesh; BISWAS, Dipshika; BROCKUNIER, Linda; BURNETTE, Duane; CHACKALAMANNIL, Samuel; CHELIAH, Mariappan, V.; CHEN, Austin; CLASBY, Martin; COLANDREA, Vince, J.; GUO, Zhuyan; HAN, Yongxin; JAYNE, Charles; JOSIEN, Hubert; MARCANTONIO, Karen; MIAO, Shouwu; NEELAMKAVIL, Santhosh; PINTO, Patrick; RAJAGOPALAN, Murali; SHAH, Unmesh; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; XIA, Yan; WO2014/25736; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem