Electric Literature of 35197-64-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, This compound has unique chemical properties. The synthetic route is as follows.
3-(3-chlorophenyl)-2-mercapto-8-methylquinazolin-4(3H)-one (1-3) was prepared as described before . 3-(3-chlorophenyl)-2-mercapto-8-methylquinazolin-4(3H)-one (1-3,211 mg, 0.70 mmol, 1.0 equiv), 2-bromo-4-(l ,3-dioxo-l,3-dihydro-2H-isoindol-2-yl)butanoic acid (3-4, 284 mg, 0.91 ramol, 1.3 equiv.), and triethyl amine (588 muL, 4.2 mmol, 6 equiv.) were dissolved in anhydrous DMF (1 mL) and stirred at 75 0C. When LCMS indicated the reaction was complete, the crude reaction mixture was partitioned between ethyl acetate and 0.1 M HCl,
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK & CO., INC.; WO2009/102537; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem