Synthetic Route of 1055412-47-9, The chemical industry reduces the impact on the environment during synthesis 1055412-47-9, name is su-5614, I believe this compound will play a more active role in future production and life.
A suspension of 5-chloro-3-(1H-pyrrol-2-yl-methylene)-1,3-dihydro-indol-2-one (260 mg, 0.96 mmol), piperidine (95 muL, 0.96 mmol) and paraformaldehyde (43 mg, 1.44 mmol) in 5 mL of dioxane and 5 mL of EtOH was heated to 80 C. for 15 h. The resulting solution was cooled to room temperature followed by cooling to -20 C. for 1 h. The solid which formed was collected by filtration and rinsed with EtOH (previously cooled to -20 C.). The solid collected was dried under vacuum to give the title compound (180 mg, 51%) as a yellow-orange solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, su-5614, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Allergan, Inc.; US6699863; (2004); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem