Reference of 5332-26-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5332-26-3 as follows.
General procedure: To a mixture of substituted benzyl bromide 3a-3o (1.0 mmol), sodium azide (3.0 mmol), alkyne 2 (1.0 mmol) in DMF/water (8:2), copper sulfate pentahydrate (10 mol%) and sodium ascorbate (20 mol%) were added. The reaction mixture was stirred for 4-16 h at room temperature, and the progress of the reaction was monitored by TLC. After completion of the reaction, ice-cold water (30 mL) was added to the reaction mixture. The residue thus obtained was filtered, washed with aqueous ammonium chloride/ammonia (9:1) solution and water and recrystallized with chloroform/hexane (8:2) to get 1,4-disubstituted 1,2,3-triazoles (4a-4o).
According to the analysis of related databases, 5332-26-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Lal, Kashmiri; Yadav, Pinki; Kumar, Ashwani; Medicinal Chemistry Research; vol. 25; 4; (2016); p. 644 – 652;,
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