Synthetic Route of 3485-84-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3485-84-5 as follows.
A mixture of 4-chlorobenzaldehyde tosyl hydrazone sodium salt (1.67g, 5.05mmol), benzyltriethylammoniumchloride (1 15mg, O.deltammol), rhodium acetate (20mg, 0.05mmol) and N-vinylphtalimide (4.32g, 25.0mmol) in dry 1 ,4-dioxane (13ml) was stirred for one day under nitrogen at room temperature. Water (35ml) was added to the mixture and the aqueous phase was extracted three times with dichloromethane. The combined organic layers were dried over Na2SO4. Evaporation gave the crude material, which was purified by flash chromatography over silicagel (eluent: hexane/ethylacetate 1 :1 ). To afford 392mg (26.3% of theory) of 2-[2-(4-chloro-phenyl)-cyclopropyl]-isoindole-1 ,3-dione in the form of a solid. 1H NMR (400MHz1 CDCI3): delta 7.73-7.62(m,4H), 7.04-7.01 (m,4H), 3.08(td,1 H,CHN), 2.50(q,1 H1CHPh), 2.19(ddd,1 H,CHH), 1.63(q,1 H1CHH). MS [M+H]+ 298/300.
According to the analysis of related databases, 3485-84-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED,; WO2007/134799; (2007); A1;,
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