Reference of 20780-72-7,Some common heterocyclic compound, 20780-72-7, name is 4-Bromoisatin, molecular formula is C8H4BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a vial containing 5b (12 mg, 0.05 mmol), TFA (11 mg,0.1 mmol) and EtOH (2.0 mL) was added 4-nitrobenzaldehyde (76 mg, 0.50 mmol). The reaction mixture was stirred for 5 min, then cyclohexanone (147 mg, 1.50 mmol) was added. The resulting mixture was stirred at room temperature for 24 h until the reaction was complete by monitoring (TLC). Next, saturated NH4Cl solution and ethyl acetate were added with vigorous stirring. The organic phase was separated, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was then purified by column chromatography on silica gel (mixture of ethyl acetate/hexane) to give the corresponding aldol adducts. The anti/syn ratio (diastereoselectivity) and ee values (enantioselectivity) were determinedby HPLC on a chiral column.
The synthetic route of 20780-72-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Lei; Gou, Shaohua; Liu, Fei; Tetrahedron Asymmetry; vol. 25; 2; (2014); p. 193 – 197;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem