Extended knowledge of 446292-07-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione

60 g (0.25 mol) of compound 6 and 400 mL of toluene were charged into a 500 mL dry three-necked flask, stirred(0.3 mol) of di-tert-butyl dicarbonate (Boc anhydride) and 0.6 g of sodium hydride were added and the system was refluxed for 48 h. TLC was detected until the reaction was complete and the partial solvent was distilled off to give 47.4 g of the white crystals of Compound 7 (93.2%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing Sibeiyuan Pharmaceutical Technology Co., Ltd.; Liu Xiaohong; Song Xingchang; Zhang Aihua; Wu Yundeng; (11 pag.)CN103951661; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem