In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5394-18-3 as follows. Computed Properties of C12H12BrNO2
N-(4-Bromobutyl)phthalimide (1.95 g, 6.89 mmol) and sodium iodide (81 mg, 0.537 mmol) were added to a suspension Of K2CO3 (1.64 g, 11.88 mmol) and 1-Boc-piperazine (1.00 g, 5.37 mmol) in acetone (25 mL) and refluxed for 22 h. The reaction mixture was filtered and the solid was washed with acetone (3 x 50 mL). The filtrate was concentrated and the residue purified by column chromatography (hexane:EtOAc, 7:3 to 0:1) to afford 2.08 g (100%) of 58. 1H NMR (500 MHz, CDCl3): delta 7.84 (dd, J = 3.0, 5.4 Hz, 2H), 7.71 (dd, J = 3.0, 5.4 Hz, 2H), 3.71 (t, J = 7.1 Hz, 2H), 3.38-3.43 (m, 4H), 2.32-2.40 (m, 6H), 1.70 (m, 2H), 1.53 (m, 2H), 1.45 (s, 9H); MS (m/z): [M+H]+ 388.4.
According to the analysis of related databases, 5394-18-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MEMORIAL SLOAN-KETTERING CANCER CENTER; CHIOSIS, Gabriela; TALDONE, Tony; RODINA, Anna; PATEL, Pallav; KANG, Yanlong; WO2011/22440; (2011); A2;,
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