Reference of 2913-97-5,Some common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, molecular formula is C10H7NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate B3-2-(1,3-dioxoisoindolin-2-yl)acetaldehyde oxime A mixture of intermediate B2 (1.46g, 1equiv), hydroxylamine hydrochloride (0.64g, 1.2equiv), anhydrous K2CO3 (1.6g, 1.5equiv) in absolute methanol (10ml) was stirred at room temperature overnight. The solvent was evaporated under reduced pressure and the residue was diluted with water, extracted with dichloromethane three times. The organic phase was combined and washed with brine, dried and solvent evaporated to give the title compound as a white solid (0.75g). 1H-NMR (d6-DMSO, 400 MHz, ca 1:1 cis-trans isomer) delta4.30/4.37 (2x d, 2H, J=4.0), 6.81/7.35 (2x t, 1H, J=4.0), 7.81-7.88 (m, 4H), 10.86/11.34 (2x s, 1H); MS (EI) m/z: 204 (M+).
The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; WANG, Kai; EP2725024; (2014); A1;,
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