Adding a certain compound to certain chemical reactions, such as: 324-03-8, name is 6-Fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 324-03-8, Formula: C8H4FNO2
7.96 g of the crude product of 6-fluoroisatin were added to 55 mE of water followed by the addition of 16.2 g (6 equivalents) of KOR while cooling with ice and stirring for 30 minutes. 9.9 g (1.5 equivalents) of bromoacetophenone were dropped into the resultant suspension while holding the internal temperature of the reaction mixture at 20 C. to 25 C. followed by additionally stirring overnight at room temperature. Afier neutralizing with concentrated hydrochloric acid, the precipitated crystals were filtered out and washed with a small amount of water. Afier adequately drying the resulting crystals, 7OmE of nitrobenzene heated to 120C. to 130C. were added a little at a time followed by further stirring for 1 hour at 140 C. to 150 C. After cooling the reaction mixture to room temperature, the precipitated crystals were washed with chloroform to obtain 5.4 g of 7-fluoro-3-hydroxy-2- methylquinoline.
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Reference:
Patent; Nippon Soda Co., Ltd.; Shibayama, Kotaro; Kuwahara, Raito; Sato, Motoaki; Nishimura, Satoshi; Shiinoki, Yasuyuki; Yokoyama, Masahiro; Kitamura, Juri; US2014/73792; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem