Some common heterocyclic compound, 74572-29-5, name is 5-Chloroisoindolin-1-one, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloroisoindolin-1-one
A mixture of 5-chloro-2,3-dihydro-isoindol-1-one (71 mg, 0.43 mmol), 5-iodo-3?,4?,5?,6?- tetrahydro-2?H- [3 ,4?]bipyridinyl- 1 ?-carboxylic acid tert-butyl ester (150 mg, 0.38 mmol) (example 15 [C]), CuT (22 mg, 0.11 mmol), (iS, 2S)-cyclohexane- 1 ,2-diamine (0.03 mL,0.22 mmol) and K3P04 (165 mg, 0.77 mmol) in dioxane (10 mL) was stuffed at 120C for2 hours. The resulting mixture was poured into water (50 mL) and the aqueous was exacted with EtOAc (30 mL, 3x). The combined organic layers were washed with brine, dried over anhy. Na2SO4 and concentrated in vacuo to get a crude product which was purified by column chromatography (EtOAc: PE = 1:1) to afford title compound (100 mg,61%) as a yellow foam. MS: 428.1 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 74572-29-5, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LI, Dongbo; LIU, Yongfu; MAERKI, Hans P.; MARTIN, Rainer E.; MAYWEG, Alexander V.; TAN, Xuefei; WANG, Lisha; WU, Jun; ZHOU, Mingwei; WO2014/191336; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem