Electric Literature of 114041-16-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 114041-16-6, name is 5,6-Dimethoxyisoindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Compound 427:Dichloropyrimidine (298 mg, 2.0 mmol) was dissolved in dry THF (10 ml_) with Et3N (280 uL, 2.0 mmol). The mixture was cooled to 0 C, and isoindoline (380 mg, 2.1 mmol) was added. The resulting mixture was warmed to room temperature and stirred for 3 hours. The EtOAc was added to dilute the mixture and the organics was washed with water, brine and dried over Na2SO4. After concentration, the residue was purified with column (silica gel, EtOAc/Hexane = 30:70) to give the product 427 (311 mg) as light yellow solid. HPLC-MS tR = 1.49 min (UV254 nm); mass calculated for formula C14H14CIN3O2 291.1 , observed LCMS m/z 292.1 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dimethoxyisoindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SCHERING CORPORATION; WO2009/14637; (2009); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem