Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 324-03-8, name is 6-Fluoroindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H4FNO2
Intermediate 1 A6-bromo-2-(trifluoromethyl)quinoline-4-carboxylic acid 300 mg (1.33 mmol) of 5-bromo-1 H-indole-2,3-dione was suspended in 3 mL water in a microwave vial. 82 mg ( 1.46 mmol) potassium hydroxide, 152 muL (2.65 mmol) acetic acid and 152 mg (1.86 mmol) sodium acetate were added so that the pH was around 5. The solution was cooled to 10 C and 238 muL (2.65 mmol) 1 ,1,1 -trifluoroacetone was added rapidly, the microwave vial was sealed and heated in the microwave for 2 h at 120 C. The reaction was stopped by the addition of 10% aqueous hydrochloric acid solution and the resulting precipitate was isolated by filtration, washed with water and dried in a vacuum drying cabinet at 50 C overnight to obtain 409 mg (1.28 mmol, 96%) of the desired title compound .1 H NMR (300 MHz, DMSO d6): delta (ppm) = 8.14 (dd, 1 H), 8.21 (d, 1 H), 8.32 (s, 1 H), 9.09 (d, 1 H), 14.50 (br. s. , 1 H)._n analogy to intermediate 1 A, 200 mg (1.21 mmol) 6-fluoro-1 H-indole-2,3-dione was heated with 217 muL (2.42 mmol) 1 ,1 ,1 -trifluoroacetone, 75 mg (1.33 mmol) potassium hydroxide, 139 muL (2.42 mmol) acetic acid and 139 mg (1.70 mmol) sodium acetate in 2 mL water for 2 h at 80 C in the microwave. As the conversion was not complete further 217 muL (2.42 mmol) 1,1 ,1 -trifluoroacetone was added to the reaction mixture and heated again for 1 h at 80 C in the microwave. Once again 217 muL (2.42 mmol) 1 ,1 ,1-trifluoroacetone was added and the reaction mixture was heated a third time for 1 h at 100 C in the microwave to obtain 227 mg (0.88 mmol, 72%) of the desired title compound after aqueous work-up.1 H NMR (300 MHz, DMSO d6): delta (ppm) = 7.83 – 7.93 (m, 1 H), 8.10 (dd, 1 H), 8.26 (s, 1 H), 8.90 (dd, 1 H), 14.51 (br. s. , 1 H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 324-03-8.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MUeLLER, Thomas; SIEBENEICHER, Holger; BUCHMANN, Bernd; CLEVE, Arwed; GUeNTHER, Judith; KOPPITZ, Marcus; HEROULT, Melanie; NEUHAUS, Roland; PETRUL, Heike; QUANZ-SCHOeFFEL, Maria; WO2015/91428; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem