Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104618-31-7, name is 2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., HPLC of Formula: C14H15NO3
General procedure: A round-bottom flask was charged with the corresponding alcohol (1.0 equiv) followed by the addition of Et2O (0.1 M). The solution was cooled to 0 C. Next, oxalyl chloride (2.0 equiv) was added dropwise. The homogeneous reaction mixture was allowed to warm to ambient temperatureand stir for 1-18 h. The reaction was cooled to 0 C and quenched by slow addition of H2O (100.0 equiv). After stirring for 1 h at room temperature, the resulting mixture was transferred to a separatory funnel, and the aqueous layer mixture was extracted with three portions of Et2O. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated under reduced pressure affording the desired oxalic acid. All the oxalates were used without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Gonzalez-Esguevillas, Maria; Miro, Javier; Jeffrey, Jenna L.; MacMillan, David W.C.; Tetrahedron; vol. 75; 32; (2019); p. 4222 – 4227;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem