6941-75-9, name is 5-Bromoisoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 6941-75-9
Preparation of 5-bromo-2,3-dihydro-1H-isoindole (13); 564.2 ml of a 1M borane/THF solution are added dropwise to 42.5 g (188 mmol) of 5-bromoisoindole-1,3-dione in 300 ml of THF (dry) at -5 C. over a period of 60 min. The mixture is subsequently stirred for 2 h at 22 C. and then for 16 h at 80 C. The mixture is then cooled to 0 C., before 200 ml of methanol (exothermic.) and 200 ml of 2M hydrochloric acid are slowly added. The resultant mixture is stirred for 3 h at 80 C., cooled to 22 C., and 100 ml of water are added. The aqueous solution is extracted three times with 150 ml of dichloromethane each time, dried over sodium sulfate, filtered and evaporated to dryness: 5-bromo-2,3-dihydro-1H-isoindole; yield 15.4 g of ?13? (41.3%); MW 198.06; Rt 1.099 min (?polar? method).
The synthetic route of 6941-75-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US2010/311745; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem