Some common heterocyclic compound, 6341-92-0, name is 6-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: indolines-derivatives
Is added to the reactor 117.6 mg (0.65 mmol) 6 – chloro – isatin and 174.8 mg (0.78 mmol) 1, 3 – diphenyl – 1, 3 – c diketone, add 50 ml tetrahydrofuran and 5 ml DMF as the reaction solvent, adding 1 ml H2O2And 14.7 mg AlCl3As the catalyst, the electric jacket heated to 70 C, magnetic stirring reflux reaction for 12 hours. Thin-layer chromatographic trace to after the reaction is complete, evaporating the solvent under reduced pressure,, the resulting mixture by silica gel column chromatography separation and purification, drying to obtain the target compound 64.1 mg, total yield of 21.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6341-92-0, its application will become more common.
Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Tian Danni; Jia Minyi; Wang Xuechuan; Dong Hao; Wang Qiang; (12 pag.)CN108558895; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem