Application of 2058-72-2, The chemical industry reduces the impact on the environment during synthesis 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, I believe this compound will play a more active role in future production and life.
General procedure: To a hot solution of 4-hydrazinylbenzenesulfonamide 2 (0.22 g,1.2 mmol) in acetic acid (15 mL), the appropriate isatin derivative 3a-c or 6a-o (1.2 mmol) was added. This mixture was heated under reflux for 6 h. The formed precipitate was filtered off while hot and washed with ethanol and petroleum ether then recrystallized fromDMF/ethanol to obtain the target compounds 4a-c and 7a-o,respectively, in 52-87% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Abo-Ashour, Mahmoud F.; Eldehna, Wagdy M.; Nocentini, Alessio; Bonardi, Alessandro; Bua, Silvia; Ibrahim, Hany S.; Elaasser, Mahmoud M.; Kry?tof, Vladimir; Jorda, Radek; Gratteri, Paola; Abou-Seri, Sahar M.; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 184; (2019);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem