In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7147-90-2 as follows. Recommanded Product: 5-Chloroisoindoline-1,3-dione
c 4-Chloro-N-(3,3,3-trifluoropropyl)phthalamic acid 3.6 g of 1,1,1-trifluoro-3-iodopropane are added dropwise to a mixture of 7.5 g of 4-chlorophthalimide and 4.6 g of potassium carbonate in 40 cm3 of dimethylformamide at a temperature in the region of 110 C. with stirring. After stirring for 11 hours at a temperature in the region of 120 C., the reaction mixture is cooled to a temperature in the region of 20 C. and then poured into 200 cm3 of water. The mixture is acidified with dilute aqueous hydrochloric acid solution to a pH of about 3, and is then extracted 3 times with 100 cm3 of ethyl acetate. The organic phase is dried over magnesium sulfate and then concentrated to dryness. 5.0 g of 4-chloro-N-(3,3,3-trifluoropropyl)phthalamic acid are thus obtained, Rf=0.12 (thin layer chromatography on silica gel, eluent: ethyl acetate).
According to the analysis of related databases, 7147-90-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Aventis Pharma Deuschland GmbH; Aventis Pharma S.A.; US2004/48916; (2004); A1;,
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