Related Products of 2058-72-2,Some common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of isatin derivatives 3 (1 mmol), proline 4 (1 mmol, 0.115 g) and chiral cinamoyl oxazolidinone 1 (1 mmol, 0.293 g) was dissolved in EtOH (80%) (5 mL) and stirred at room temperature for about 5 h. After completion of the reaction (TLC), the solvent was evaporated under reduced pressure, the products (5a-i) were obtained in quantitative yields; and for future purification they were washed with cold EtOH.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1-methylindoline-2,3-dione, its application will become more common.
Reference:
Article; Taghizadeh, Mohammad Javad; Arvinnezhad, Hamid; Samadi, Saadi; Jadidi, Khosrow; Javidan, Abdollah; Notash, Behrouz; Tetrahedron Letters; vol. 53; 38; (2012); p. 5148 – 5150;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem