Application of 56341-39-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56341-39-0 name is 6-Fluoroindolin-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
At 130 C., 82.5 g of 6-fluoro-2-indolinone (starting material IV) are stirred in 180 ml acetic anhydride for 3 hours. After cooling to room temperature, the precipitate is filtered off with suction, washed with 100 ml of petroleum ether and dried. [0256] Yield: 64.8 g (61% of theory) [0257] Rf value: 0.75 (silica gel, petroleum ether/ethyl acetate=1:1) [0258] C10H8FNO2 [0259] Mass spectrum: m/z=192 [M-H]-
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Fluoroindolin-2-one, and friends who are interested can also refer to it.
Reference:
Patent; Boehringer Ingelheim Pharma GmbH & Co. KG; US2005/43389; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem