In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 366453-22-7 as follows. Recommanded Product: 4-Methoxyisoindolin-1-one
To an ice-cold solution of 2c (291 mg, 1.78 mmol) in CH2Cl2 (20 mL) was added a 1.0 M BBr3 solution in CH2Cl2 (3.6 mL, 3.6 mmol). The cold bath was then removed and the resulting solution was stirred for 16 h at ambient temperature. The reaction was carefully quenched by addition of water and the mixture was extracted with EtOAc. The combined organic layers were washed with water and brine, dried (MgSO4), filtered and evaporated to dryness to give 2d (232 mg, 87% yield) as beige solid.
According to the analysis of related databases, 366453-22-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Boehringer Ingelheim (Canada) Ltd.; US2004/106791; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem