In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6341-92-0, name is 6-Chloroisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 6-Chloroisatin
153.8 mg (0.85 mmol) 6-chloroisatin, 102.1 mg (1.02 mmol) 2,4-pentanedione, 50 mL toluene and 5 mL DMF as solvent, 13.6 mg KMnO4 and 7.5 mg MnO2, and 20 mg strong acid ion exchange resin D001 as catalyst were added to a 100 mL round flask. The mixture was stirred and heated at 115 C. for 9 hours. The reaction was monitored with TLC. When TLC indicated that reaction was complete, heating was removed. The reaction mixture was concentrated, filtered, and washed with toluene to obtain 127.2 mg desired product (compound 8), a yield of 56.9%. 1H-NMR (300 MHz, DMSO-d6) delta (ppm): 10.87 (1H, s), 7.21 (1H, d), 6.85 (1H, s), 6.73 (1H, d), 2.28 (3H, s), 2.23 (3H, s); 13C-NMR (75 MHz, DMSO-d6) delta (ppm): 165.5, 164.1, 153.5, 136.8, 128.4, 126.3, 121.3, 115.9, 106.3, 92.5, 23.9, 11.8; MS (ESI) for (M+Na)+: 286.0.
The synthetic route of 6341-92-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY; Liang, Chengyuan; Tian, Danni; Jia, Minyi; (11 pag.)US10035808; (2018); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem