Adding a certain compound to certain chemical reactions, such as: 13861-75-1, name is Spiro[cyclopropane-1,3′-indolin]-2′-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13861-75-1, Recommanded Product: 13861-75-1
A. Preparation of 5′-(1-oxopropyl)spiro-[cyclopropane-1,3′-[3H]indol]-2′(1’H)-one A slurry was made from 7.5 ml of dimethylformamide and 45.5 g of anhydrous aluminum chloride. The temperature rose to 40 C. and 2.97 ml of propionyl chloride and 5.43 g of spiro[cyclopropane-1,3′-[3H]-indol]-2′(1’H)-one were added. The mixture was stirred for 2 hours at 70 C. and was slowly poured into a mixture of ice and 50 ml of concentrated hydrochloric acid. After cooling overnight, the resulting precipitate was recovered by filtration. Crystallization from ethyl acetate provided 4.9 grams of the desired subtitle intermediate, m.p. 183-185 C. Analysis for C13 H13 NO2: Calculated: C, 72.54; H, 6.09; N, 6.51; Found: C, 72.47; H, 6.14; N, 6.42.
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Reference:
Patent; Eli Lilly and Company; US4617302; (1986); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem