Synthetic Route of 3676-85-5, A common heterocyclic compound, 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 98 N-(1,3-Dioxo-2,3-dihydro-1H-5-isoindolyl)-N’-(2,3,4,5,6-pentafluorobenzyl)urea Diphenylphosphoryl azide (248 mg, 0.90 mmol, 1.2 eq) and triethylamine (91 mg, 0.90 mmol, 1.2 eq) were added to a solution of 2,3,4,5,6-pentafluorophenylacetic acid (158 mg, 0.75 mmol) in toluene, and the mixture was stirred at 110C for 60 min. Thereafter, 4-aminophthalimide (59 mg, 0.75 mmol, 1.0 eq) and a minor amount of DMF were added thereto, and the mixture was stirred at 110C for 2.5 hr. After the completion of the reaction, water and ethyl acetate were added thereto, and the precipitated crystal was collected by filtration and was washed with ethyl acetate to give the title compound as a crystal (12 mg, 7.0%). MS m/z: 385 1H-NMR delta: 4.45 (2H, d, J = 5.12 Hz), 7.07 (1H, t, J = 5.98 Hz), 7.58 (1H, dd, J = 1.71, 8.05 Hz), 7.66 (1H, d, J = 8.05 Hz), 7.97 (1H, d, J = 1.95 Hz), 9.30 (1H, s), 11.09 (1H, s)
The synthetic route of 3676-85-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1256574; (2002); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem