Adding a certain compound to certain chemical reactions, such as: 7147-90-2, name is 5-Chloroisoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7147-90-2, Application In Synthesis of 5-Chloroisoindoline-1,3-dione
Protected with nitrogen, cooled to 0 C in an ice bath, added 1.0 g (5.5 mmol) of 5-chloroimphthalate to the reaction flask, added 30 ml of DCM, and contained 1.3 g (8.62 mmol) of n-butylmagnesium bromide. THF solution (8ml) was added dropwise to the reaction flask, and the reaction was performed in an ice bath for 1.5 hours. TLC showed no reaction. The temperature was raised to room temperature, and 1.5 equivalents of n-butyl magnesium bromide Grignard reagent were added. The reaction was performed for 2.5 hours. The reaction was shown to be complete. The reaction wasquenchedwith saturated NH4Cl, extracted with DCM, dried, concentrated, and subjected to silica gel column chromatography. A mixture of ethyl acetate and petroleum ether was used as the eluent (the volume ratio of ethyl acetate and petroleum ether was 1: 1), to obtain a mixture of 3-n-butyl-5-chloro-3-hydroxyisoindolin-1-one and 3-n-butyl-6-chloro-3-hydroxyisoindolin-1-one, Yield 45.5%,
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloroisoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Aisite (Chengdu) Bio-pharmaceutical Co., Ltd.; Fu Jiasheng; Chen Xing; Yang Youzhe; Chen Xiaogang; Chen Jiachang; Sun Jingxiong; Gan Man; Guo Peng; (41 pag.)CN110563631; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem