Synthetic Route of 875003-43-3,Some common heterocyclic compound, 875003-43-3, name is 7-Fluoro-1-methylindoline-2,3-dione, molecular formula is C9H6FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture 7-fluoro-1-methylisatin (K1.3.54 g, 19.8 mmol) and 3-(tert- butyldiphenylsilyloxy)propan-1 -amine (6.90 g, 22.0 mmol) in EtOH (50 ml_) was heated at 60 C for 2 h then concentrated to provide 9.55 g (100%) of product K2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Fluoro-1-methylindoline-2,3-dione, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; VOIGT, Johannes, H.; WO2008/137139; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem