897957-06-1, name is 6-Bromo-1-methylindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 897957-06-1
A solution of {S)-tert-hvXy 4-(l-amino-l-oxo-3-(4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl)propan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 16, step (i), 200 mg) and 6-bromo-l-methylindolin-2-one (87 mg) in acetonitrile (5 mL) was treated with potassium carbonate (107 mg) and purged with nitrogen. 1,1 bis(Di-tert- butylphosphino)ferrocene palladium dichloride (15 mg) was added and the reaction stirred under reflux under nitrogen for 4 h and then evaporated in vacuo. The residue was partitioned between water (40 mL) and ethyl acetate (40 mL). The aqueous was further extracted with ethyl acetate (40 mL) and the combined organic extracts were dried over magnesium sulfate and evaporated in vacuo. The crude product was purified by flash silica chromatography eluting with ethyl acetate. Pure fractions were evaporated to dryness to afford the sub-titled compound (45 mg).1H NMR (399.824 MHz, CDCl3) delta 7.54 (d, 2H), 7.32 – 7.28 (m, 3H), 7.22 (d, IH), 6.97 (s, IH), 6.88 – 6.80 (m, IH), 6.49 (d, IH), 5.27 (s, IH), 4.90 (s, IH), 4.80 (q, IH), 3.89 – 3.82 (m, IH), 3.69 – 3.62 (m, IH), 3.60 – 3.48 (m, 4H), 3.32 – 3.18 (m, 5H), 2.33 – 2.24 (m, IH), 1.92 – 1.76 (m, 2H), 1.35 (s, 9H).m/e (Multimode+) 437 [M+2H-BOC]+
The synthetic route of 897957-06-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FORD, Rhonan; METE, Antonio; MATHER, Andrew; MILLICHIP, Ian; WO2010/128324; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem