Related Products of 100510-65-4, A common heterocyclic compound, 100510-65-4, name is 6-Amino-3,3-dimethylindolin-2-one, molecular formula is C10H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of compound 8 (100 mL, compound 7, 23.7 mmol from 5.3 g) at 0 to 5 degrees, a methylene chloride solution of compound 23 (4.0 g, 18.8 mmol) and triethylamine (2.6 mL, 18.8 mmol) was added dropwise. The reaction solution was stirred at room temperature overnight, washed with aqueous sodium bicarbonate solution, washed with water, the organic phase was concentrated under reduced pressure, filtered, and the filter cake was washed with a small amount of dichloromethane, and dried in vacuo to give an off-white solid compound 24 (5.2 g, yield 65.7%).
The synthetic route of 100510-65-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou Ruiming Drug Discovery Co., Ltd.; Zhang Fei; Feng Zixia; (33 pag.)CN110950868; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem