Synthetic Route of 446292-08-6, A common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
210.7 g (0.5 mol) of (S)-2-{[2-oxo-3-(4-(3-oxomorpholine)benzene] prepared in Example 7 was added to the reaction flask.Based on oxazolidine-5-yl]methyl}isoindole-1,3-dione (formula VII), 1500 ml of anhydrous ethanol,500 ml of a 30% aqueous solution of methylamine was stirred and heated to 40C to 60C for 8 hours.TLC control (dichloromethane:methanol = 20:1, volume ratio) reaction is complete, with 10% hydrochloric acid to adjust the pH to between 1-2, precipitated a lot of white solids, cooled to about 15 C, stirred for 2 hours, filtered The filter cake was washed with 300 ml of anhydrous ethanol and dried under reduced pressure to obtain 147.0 g of a white solid (compound of formula VIII) with a molar yield of 89.7% and an HPLC purity of 98.7%.
The synthetic route of 446292-08-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Peking University Fangzheng Group Co., Ltd.; Peking University Pharmaceutical Co., Ltd.; Peking University Medical Treatment Industrial Group Co., Ltd.; Xu Hong; Fan Yang; Zhang Zheng; Wang Wei; Ren Juan; (14 pag.)CN105085431; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem