Reference of 552330-86-6, The chemical industry reduces the impact on the environment during synthesis 552330-86-6, name is 5-Bromoisoindolin-1-one, I believe this compound will play a more active role in future production and life.
Combine 4-bromo-2-bromomethyl-benzoic acid methyl ester (3.0 g, 9.7 mmol) and 7M NH3 in methanol (100 mL, 700 mmol) in a sealed tube and heat in a 40C oil bath for 18 hours. Cool the resulting suspension to room temperature and filter to obtain 1.5 g of 5-bromo-2, 3-dihydro-isoindol-1-one (72 %). Combine 5-bromo-2, 3-dihydro-isoindol-1-one (1. 1 g, 5.0 mmol), bis- pinocalatodiboron (1.4 g, 5.5 mmol), [1, l’-Bis (diphenylphosphino) – ferocene] dichloropaladium (II) complex with dichloromethane (408 mg, 0.5 mmol) and potassium acetate (1.5 g, 15.0 mmol) in a 200 mL flask with a septum. Add dimethyl sulfoxide (27 mL) and heat in a 90C oil bath for 18 hours. Cool the resulting slurry to room temperature and dilute with water (100 mL). Extract the resulting slurry with dichloromethane (3 x 75 mL). Wash the combined organic layers with brine (40 mL), dry (Na2S04), filter and concentrate in vacuo to obtain 1.6 g of a mixture of the title product and bis-pinocalatodiboron (1: 0.05), which is used without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromoisoindolin-1-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/73205; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem