Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 868066-91-5, name is 5-Bromo-2-methylisoindolin-1-one, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Bromo-2-methylisoindolin-1-one
Synthesis of 5-bromo-2,3-dimethylisoindolin-1-one (2) To a solution of 5-bromo-2-methylisoindolin-1-one (1, 1 g, 4.42 mmol) in tetrahydrofuran (20 mL) at -78° C., sodium hexamethyldisilazane (4.4 mL, 4.86 mmol 1M solution in tetrahydrofuran) was added and the reaction mixture was allowed to stir at the same temperature for 15 min. Methyl iodide (0.55 mL, 8.85 mmol) was added and the reaction mixture was stirred at -78° C. for 2 h. The reaction mixture was quenched with water and extracted with ethyl acetate. The organic layer was washed with brine, separated, dried over sodium sulphate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using 30percent ethyl acetate in hexanes as eluent to afford 5-bromo-2,3-dimethylisoindolin-1-one (2). Yield: 0.1 g, 9percent; MS (ESI) m/z 240 [M+1]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 868066-91-5.
Reference:
Patent; eFFECTOR Therapeutics, Inc.; Sprengeler, Paul A.; Reich, Siegfried H.; Ernst, Justin T.; Webber, Stephen E.; Shaghafi, Mike; Murphy, Douglas; Tran, Chinh; (131 pag.)US10112955; (2018); B2;,
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