Related Products of 5181-35-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5181-35-1, name is 2-(2-Bromoethoxy)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.
Compound VII: Weigh 2.3g o-nitrobenzyl mercaptan (14.2mmol) And 5.73g of N-(2-bromoethoxy)phthalimide (21.3mmOl) in a round bottom flask, Dissolved with 25ml dimethyl sulfoxide, To the reaction solution was added 3ml of triethylamine (21.3mmol), and reacted at room temperature for 4h; TLC monitoring showed that o-nitrobenzyl mercaptan was completely consumed. To the reaction mixture, an appropriate amount of water was added and the mixture was extracted with dichloromethane for 2-3 times. The organic phase was collected, dried over anhydrous sodium sulfate, Separation by column chromatography (RhoEpsilon:EpsilonAlpha = 5:1), 3.74 g of compound VII (N- (2 – ((2-nitrobenzyl) mercapto) ethoxy) phthalimide was obtained as a white solid (73.2% yield). As shown in FIG. 4, FIG. 4 is a nuclear magnetic hydrogen spectrum of the compound YPi11 prepared in this example.
The chemical industry reduces the impact on the environment during synthesis 2-(2-Bromoethoxy)isoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; University of Science and Technology of China; Huang Jianfeng; Shi Jing; Chu Guochao; (21 pag.)CN107698474; (2018); A;,
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