Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 496-12-8, name is Isoindoline, A new synthetic method of this compound is introduced below., Safety of Isoindoline
General procedure: To a mixture of tert-butyl-3-bromopropylcarbamate 1.2 (5.6mmol, 1.3 eq, 1.3g) and N,N-disubstituted amine (4.3mmol, 1 eq) in 30mL of DMF was added potassium carbonate (13.0mmol, 3 eq, 1.8g). The resulting mixture was heated at 70C for 24h. Then, the solvent was removed under reduced pressure and water (80mL) added to the residue. The crude product was extracted with 3×60mL of DCM. The combined organic fractions were washed with 60mL of water and dried over magnesium sulphate. The solvent was evaporated and the crude product collected as yellow oil. Purification by column chromatography (DCM: MeOH(NH3), 9.7:0.3 (v/v)) was performed.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Donnier-Marechal, Marion; Carato, Pascal; Larchanche, Paul-Emmanuel; Ravez, Severine; Boulahjar, Rajaa; Barczyk, Amelie; Oxombre, Benedicte; Vermersch, Patrick; Melnyk, Patricia; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 964 – 978;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem