Reference of 89-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-40-7, name is 5-Nitroisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
4-Nitrophthalimide (LOOGR) was taken into a hydrogenation vessel and dissolved using 600ML OF DIMETHYLFORMAMIDE. Raney nickel catalyst (20gr, wet) was added to the solution and hydrogenated initially at 20-30C under 20-40psi pressure. After the exothermic nature of the reaction was over, hydrogen pressure was increased to 40-60psi and the temperature to 40-50C. After the hydrogenation is over the reaction mixture was filtered while hot and the catalyst removed by filtration. Dimethylformamide was removed from the filtrate under reduced pressure at 60-80C. Water (500ML) was added to the residue and the mixture stirred for 20-30MIN. The product was isolated by filtration and dried at 60-70C to get a yellow crystalline solid of 4-aminophthalimide (82gr, 97%). Melting point: 293-5C.
The synthetic route of 5-Nitroisoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NATCO PHARMA LIMITED; VENKAIAH CHOWDARY, Nannapaneni; WO2004/43919; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem