Related Products of 15362-40-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
The material 2,6-dichlorodiphenylamine (IV) (15mmol, 3.572g) was dissolved in 50ml toluene solvent and added to a three-necked flask, chloroacetyl chloride (16.5mmol, 1.8637g) was added dropwise, heated to 120 , Stir the reaction for 3h,TLC detected that the reaction of 2,6-dichlorodiphenylamine (IV) was completed and cooled to room temperature. [Et3NH]Cl-AlCl3 (30mmol, 8.129g) was slowly added dropwise to the reaction solution, stirred at room temperature for 30min, the oil bath was heated to 60C, and the reaction was stirred for 4h.TLC monitoring until the N-phenyl-N-(2,6-dichlorophenyl)chloroacetamide (III) intermediate disappeared, the reaction solution was slowly poured into a separatory funnel, allowed to stand for separation, and the ions were separated The liquid is recovered and applied. The application effect is shown in Table 1. The organic layer is added dropwise with 10% NaOH (30mmol, 1.2g) and heated to reflux for 2h.TLC monitors the completion of the reaction of 1-(2,6-dichlorophenyl)-2-indoline (II) intermediate, separates and removes the organic layer, evaporates part of the water from the water layer under reduced pressure, cools and crystallizes, Recrystallized with water,4.035g of white solid was obtained with a yield of 84.56%,The HPLC content is 99.85%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,6-Dichlorophenyl)-2-indolinone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhejiang University of Technology; Luo Shuping; Xu Dandan; Ren Chenchao; Wang Tianqi; (6 pag.)CN111116391; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem