In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20876-36-2, name is 5-Aminoindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H8N2O
153 mg (0.490 MMOL) (5-Bromo-2-chloro-pyrimidin-4-yl)-phenethyl-amine was taken into 500 OL 1,4 dioxane with 140 DL (1.00 MMOL) diisopropylethylamine and 80 mg (0.539 mmol) 5-amino-1, 3-dihydro-indol-2-one. The reaction was allowed to heat to 110 C for sixteen hours. The resulting brown glass was taken into 92.3 : 7: 0.7 CHCI3 : CH30H : NH40H and washed with 1 N sodium hydroxide. The organic layer was dried over magnesium sulfate and evaporated directly onto silica gel. This adsorbed compound was purified via column chromatography (97.8 : 2: 0.2 CHCI3 : CH30H: NH40H) over silica to isolate the major product. During evaporation of the major fractions, a white precipitate is noted. Filtration of this precipitate prior to mLete evaporation afforded the title compound in 6percent yield as a white solid. CZOHBRNSO : MS: 424.2/426. 2 (MH+) ;’H NMR (D6-DMSO) 10.20 (s, 1 H), 9.01 (s, 1 H), 7.93 (s, 1 H), 7.52 (s, 1 H), 7.44 (d, J = 8.4 Hz, 1 H), 7.28-7. 16 (m, 5 H), 6.97 (m, 1 H), 6.65 (d, J=8. 3HZ, 1 H), 3.56 (m, 2 H), 3.31 (s, 2 H), 2.82 (t, J = 7.9 Hz, 2 H) ppm.
The synthetic route of 20876-36-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/56786; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem