Introduction of a new synthetic route about 5394-18-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 5394-18-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 5394-18-3

To a solution of N-(4-bromobutyl)phthalimide (8g, 0.03mol) in ethanol (50ml) was added morpholine (2.97ml, 0.034mol) and triethylamine (7.9ml, 0.06mol). The reaction was then refluxed under N2 atmosphere for 2Oh after which LC-MS indicated the clean formation of 2- [4-(4-morpholinyl)butyl]-1 H-isoindole-1 ,3(2H)-dione. The reaction mixture was cooled to ambient temperature followed by the addition of hydrazine hydrate (3.26ml, 0.057mol). The reaction mixture was brought up for reflux again for 30min during which a white precipitate was formed. The reaction mixture was cooled to room temperature before the white precipitate was filtered and the filtrate passed through an SCX column (eluting with 100% methanol followed by 10% 2M ammonia in methanol) to afford 4-(4-morpholinyl)butyl]amine (1.8g, 41%).; 4-(4-Morpholinyl)butyl]amineA solution of morpholine (3ml, 34.9mmol), N-(4-bromobutyl)phthalimide (8g, 29mmol) and triethylamine (8ml, 58mmol) in ethanol (55ml) was refluxed for 16h, by which the LC-MS showed reaction completion. The reaction was cooled to room temperature. Ethanol (10ml) and hydrazine hydrate (6ml, 58mmol) were added and the mixture refluxed for 20min, by which a white solid crashed out. The reaction was filtered and the filtrate passed through SCX with methanol followed by 10% 2M ammonium hydroxide in methanol. The latter fractions eluted with 10% ammonium hydroxide in methanol were combined and concentrated in vacuo to afford a bright yellow oil (3g). ELSD LC-MS, (MH+=I 59).

According to the analysis of related databases, 5394-18-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/71577; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem