Application of 603-62-3,Some common heterocyclic compound, 603-62-3, name is 3-Nitrophthalimide, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of potassium hydroxide (16.1 g, 286 mmol) in water (500mL), was added 3-nitrophthalimide (25.0 g, 130 mmol) in portion at 0 C. The suspensionwas stirred at 0 C for 3 hrs, and then heated to 30 C for 3 hrs. To the solution, was addedHC1 (100 mL, 6N). The resulting suspension was cooled to 0 C for 1 hr. The suspension was filtered and washed with cold water (2 x 10 mL) to give 3-nitro-phthalamic acid as awhite solid (24.6 g, 90% yield): ?HNMR(DMSO-d6) 5 7.69 (brs, 1H, NHJ]), 7.74 (t, J 8 Hz, 1H, Ar), 7.92 (dd, J= 1, 8Hz, 1H, Ar), 8.13 (dd, J= 1, 8Hz, 1H, Ar), 8.15 (brs, 1H, NHJ]), 13.59 (s, 1H, 01]); ?3CNIVIR(DMSO-d6)5 125.33, 129.15, 130.25, 132.54, 136.72, 147.03, 165.90, 167.31.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Nitrophthalimide, its application will become more common.
Reference:
Patent; CELGENE CORPORATION; HAGNER, Patrick; GANDHI, Anita; POURDEHNAD, Michael; (67 pag.)WO2017/96024; (2017); A1;,
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