Reference of 15861-30-0, A common heterocyclic compound, 15861-30-0, name is Indoline-5-carboxylic acid, molecular formula is C9H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of indoline-5-carboxylic acid (500 mg, 3.07 mmol) in DMF (3 mL) was added Pyridine (0.2 mL) at 0 C followed by acryloyl chloride (555 mg, 6.13 mmol). The reaction mixture was stirred at RT for 5 h. The mixture was then concentrated, DCM was added (20 mL), washed with 0.5N HC1 (10 mL), dried over Na2504, filted and concentrated in vacuo to afford 1- acryloylindoline-5-carboxylic acid (280 mg, 42%) as a yellow solid. [M+H] Calc?d for C12H11N03:218.1; Found: 218.1
The synthetic route of 15861-30-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KINNATE BIOPHARMA INC.; KANOUNI, Toufike; ARNOLD, Lee D.; KALDOR, Stephen W.; MURPHY, Eric A.; TYHONAS, John; (0 pag.)WO2020/6497; (2020); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem