Application of 15861-30-0, These common heterocyclic compound, 15861-30-0, name is Indoline-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2, 3-Dihydro-1H-indole-5-carboxylic acid (12.4 mmol) was dissolved in DMF (5 mL) and 1, 2-dichloroethane (40 mL). DIPEA (12.4 mmol), 1- (3-dimethylaminopropyl)- 3-ethyl-carbodiimide hydrochloride (12.4 mmol), 1-hydroxybenzotriazole (12.4 mmol) and 2-aminothiazole (12.4 mmol) was added. Stirred at 50 C for 48h. HC1 (2M) (12.4 mmol) was added to the reaction mixture followed by water (30 mL). This gave a heavy precipitation which was removed by filtration. The solid was washed with water and 1,2-dichloroethane and dried. Yield: 56% 1H NMR (D6-DMSO) : 6.60 (s, 1H); 7.26 (d, 1H); 7.44-7. 54 (2H); 7.56 (d, 1H); 7. 86 (d, 1H); 8.45 (s, 1H) ; 11.51 (br s, 1H).
The synthetic route of 15861-30-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; WO2005/39572; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem