Application of 2436-29-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
B] Preparation of compound 1-B; 0.38 g (0.99 mmol) of compound 1-A is dissolved in 15 ml methanol and 0.26 g (1.28 mmol) of 3-(l,3-dioxo-l,3-dihydroisoindol-2-yl)-propionaldehyde, 0.1 ml acetic acid and 0.125 g (1.98 mmol) OfNaBH3CN are added to the solution. The mixture is stirred at 28C for 3.5 hours and the solvent is subsequently evaporated. The crude product is purified by column chromatography on silica gel (petroleum ether(ethyl acetate 10:1 -> 5:1) to give 380 mg (65%) of the desired product as a light yellow solid.
The synthetic route of 3-(1,3-Dioxoisoindolin-2-yl)propanal has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASILEA PHARMACEUTICA AG; KELLENBERGER, Johannes, Laurenz; DREIER, Juerg; WO2011/18510; (2011); A1;,
Indoline – Wikipedia,
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