Application of 17564-64-6,Some common heterocyclic compound, 17564-64-6, name is 2-(Chloromethyl)isoindoline-1,3-dione, molecular formula is C9H6ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0214] In order to preparation the phthalimidomethyl quarternary salt of Compound 1101, a mixture of 100 mg Compound 1101 and 100 mg sodium iodide (2.0 equivalents) were dissolved in 3.0 ml dry acetonitrile. To the mixture was added 128 mg of chloromethylphthalimide and the vial was heated in an oil bath at 55 C for four days. The product was identified by LCMS as a new peak with RF= 3.984, M+ = 467
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Chloromethyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Patent; SEMAFORE PHARMACEUTICALS, INC.; GARLICH, Joseph, R.; DURDEN, Donald, L.; WO2004/89925; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem