Adding a certain compound to certain chemical reactions, such as: 32692-19-6, name is 5-Nitroindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32692-19-6, Recommanded Product: 32692-19-6
Example 7 1-methylethyl 4-[4-(5-nitro-2,3-dihydro-1H-indol-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate; [Show Image] To a mixture of 5-nitro-2,3-dihydro-1H-indole (328 mg, 2.00 mmol), 1-methylethyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidine-1-carboxylate (323 mg, 1.00 mmol) obtained in Reference Example 3, and N,N-dimethylformamide (10 mL) was added potassium carbonate (830 mg, 6.01 mmol), and the mixture was stirred at 100C for 2 days. The reaction mixture was allowed to cool to room temperature, water was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated. The residue was crystallized from ethyl acetate to give the title compound as yellow crystals (175 mg, yield 39%). 1H-NMR (300 MHz, CDCl3)delta:1.28 (d, J = 6.0 Hz, 6 H), 1.82 – 1.99 (m, 2 H), 2.02 – 2.16 (m, 2 H), 2.91 – 3.08 (m, 2 H), 3.38 (t, J = 8.7 Hz, 2 H), 4.29 – 4.46 (m, 2 H), 4.65 (t, J = 8.7 Hz, 2 H), 4.87 – 5.02 (m, 2 H), 6.65 (d, J = 3.8 Hz, 1 H), 7.16 (d, J = 3.8 Hz, 1 H), 8.08 (s, 1 H), 8.17 (dd, J = 9.0, 2.3 Hz, 1 H), 8.57 (s, 1 H), 8.62 (d, J = 9.4 Hz, 1 H).
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Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2399914; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem