These common heterocyclic compound, 129487-92-9, name is tert-Butyl 5-aminoindoline-1-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: tert-Butyl 5-aminoindoline-1-carboxylate
A mixture of 2-isopropoxy-4-methylbenzoic acid (2.57 g), tert-butyl 5-AMINO-1-INDOLINECARBOXYLATE (3.41 g), 1- hydroxybenzotriazole hydrate (2.13 g) and 1- [3- (dimethylamino) PROPYL]-3-ETHYLCARBODIIMIDE (2.16 g) in N, N- dimethylformamide (30 ml) was stirred at ambient temperature overnight. The reaction mixture was poured into a mixture of ethyl acetate and water, and the organic layer was washed with brine and dried over magnesium sulfate. The solvent was concentrated in vacuo and the precipitate was collected by filtration to give tert-butyl 5- [ (2-ISOPROPOXY-4- methylbenzoyl) AMINO]-1-INDOLINECARBOXYLATE (4.82 g). 1H-NMR (DMSO-d6): 8 1. 38 (3H, d, J=6.02 Hz), 1.51 (9H, S), 2.36 (3H, s), 3.07 (2H, t, J=8.36 Hz), 3.91 (2H, t, J=8.36 Hz), 4.75-4. 80 (1H, m), 6.89 (1H, d, J=7.98 Hz), 7.04 (1H, s), 7.41 (1H, s), 7.63-7. 69 (2H, m), 7.71 (1H, d, J=7.98 Hz), 10.01 (1H, s)
The synthetic route of tert-Butyl 5-aminoindoline-1-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; DAISO CO., LTD.; WO2004/39795; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem