Reference of 1336963-95-1, A common heterocyclic compound, 1336963-95-1, name is 6-Bromo-7-fluoroindoline-2,3-dione, molecular formula is C8H3BrFNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 73-(1 ,4′-bipiperidin-1 ‘-ylmethyl)-7-bromo-8-fluoro-//-(1 -phenylcvclopropyl)-2-r3- (trifluorometh l)phenyll-4-quinolinecarboxamide7-bromo-8-fluoro-3-methyl-2-r3-(trifluoromethyl)phenyll-4-quinolinecarboxylic acidTo a solution of 6-bromo-7-fluoro-1 H-indole-2,3-dione (19 g, 77.8 mmol) in THF (200 mL) was added a solution of KOH (21.8 g, 389 mmol) in water (100 mL) dropwise. After the addition was complete, 1-[3-(trifluoromethyl)phenyl]-1 -propanone (15.73 g, 77.8 mmol) was added and the mixture was heated to reflux for 1.5 h. The THF was removed in vacuo, and the remaining aqueous solution was washed with diethyl ether (3 x 100 mL) and acidified with 1 N HCI to pH 2. The precipitate was collected by filtration to afford 7-bromo-8-fluoro-3- methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid (16 g, 68% yield).
The synthetic route of 1336963-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen; WO2011/119704; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem