In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 337536-15-9, name is 4-Bromoisoindolin-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4-Bromoisoindolin-1-one
Step 1. A mixture of 2,4-dichloropyrimidine (116 mg, 0.78 mmol), 4-bromoisoindolin-l-one (150 mg, 0.71 mmol), K2CO3 (196 mg, 1.41 mmol) in DMF (3 mL) was degassed and purged with N2 three times, and then the mixture was stirred at 80C for 14 hours under an inert atmosphere. The resulting mixture was filtered and concentrated under reduced pressure. Purification by prep-TLC (Si02, petroleum ether/ethyl acetate = 3 : 1) provided 9 (80 mg) as a light yellow solid which was used directly in the next step without further purification.
The synthetic route of 337536-15-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NUMERATE, INC.; RAIMUNDO, Brian; KOLTUN, Elena S.; GRIFFIN, John; STANGELAND, Eric; (93 pag.)WO2018/49324; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem