Some common heterocyclic compound, 41663-84-7, name is 2-Methyl-5-nitroisoindoline-1,3-dione, molecular formula is C9H6N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H6N2O4
Example 4. To a reaction vessel were added 4-nitro-N-methylphthalimide (0.51g, 0. 00248 mol), sodium hydrogen sulfide (0.07g, 0.00125 mol), biphenyl (0.204g, 0.00132 mol), triethylamine (0.2 ml, 0.0014 mol), tetrabutylphosphonium bromide (0.15g, 0.00044 mol) and dry toluene (40 ml). The reaction mixture was allowed to proceed at reflux (approximately 145C) for 18 hours. The reaction mixture was sampled and tested by HPLC which indicated a yield of 4,4′-bis(N-methylphthalimide)sulfide of 10% (0.04g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41663-84-7, its application will become more common.
Reference:
Patent; GENERAL ELECTRIC COMPANY; EP172298; (1991); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem