Research on new synthetic routes about 14192-26-8

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14192-26-8 as follows. Recommanded Product: Methyl 2-oxoindoline-6-carboxylate

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14192-26-8 as follows. Recommanded Product: Methyl 2-oxoindoline-6-carboxylate

In a 250ml reaction flask was added 28.7g of 2-oxindole-6-carboxylic acid methyl ester, 130ml ethanol, stirred open, then added 16.8ml (17.6g) benzaldehyde, 2.97 mL piperidine was heated to 70 -80C, after 2 hours the reaction was allowed to cool to 20 C- 30C, the precipitate was filtered, the filter cake was washed with ethanol, and dried under vacuum 5 hours 50 deg.] C give a yellow solid 40.2g (IV of), yield: 96.0%.

According to the analysis of related databases, 14192-26-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hangzhou Simbos Pharm Co., Ltd; Li, Yong; Hu, wei; Du, Huanda; Wang, wanqing; Liu, YanHua; (8 pag.)CN105461609; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem