Some common heterocyclic compound, 88150-75-8, name is Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate, molecular formula is C16H17NO6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 88150-75-8
(B.) From ethyl 4-[2-(phthalimido)ethoxy]acetoacetate STR54 Ethyl 4-[2-(phthalimido)ethoxy]acetoacetate (200 g) was dissolved in isopropanol (1000 ml) and to this was added 2-chlorobenzaldehyde (88.1 g) and methyl 3-aminocrotonate (72.2 g). The mixture was refluxed for 21 hours then the methanol was evaporated to leave an oil which was dissolved in acetic acid (1000 ml). After granulating overnight, the precipitate was collected, washed with acetic acid then slurried in methanol (300 ml). Filtration gave the title compound the n.m.r. and ir of which were identical with those of the material prepared by part (A) above.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 88150-75-8, its application will become more common.
Reference:
Patent; Pfizer Inc.; US4572909; (1986); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem